The objective of this study was to investigate clinical characteristics of placental site nodules and plaques. A clinocopathological study was made on a series of 8 cases of placental site nodules and plaques retrospectively, treated at the
Department
of Obstetrics & Gynecology, Seigang Hospital from 1992 to 1996.
@ES The results obtained as follows:
@EN 1. The lesions occurred on patients 25 to 39 years of age, and were discovered in an endometrial curettage specimen performed because of menorrhagia or vaginal bleeding.
2. The interval from the most recent known pregnancy to the time of presentation ranged from 1 month to 13 month(average 3.8 months) in this study in which this information was available.
3. Urine pregnancy tests were negative in all 8 cases.
4. Three of patients in this category had undergone normal vaginal delivery, four had undergone cesarean section and one had undergone D&C before presentation.
5. Microscopic examination disclosed single or multiple, mostly well-circumscribed, oval, or plaquelike, variably cellular nodules that were characteristically extensively hyalinized. The lesional cells typically had abundant cytoplasm that was
amphophilic, eosinophilic, or occasionally vaculoated, and irregular, often degenerative-appering nuclei; mitotic figures were absent or rare. Chronic endometritis of variable degree evidenced by plasma cells was noted.
Clinically, placental site nodule or plaque is confused with retained placenta, placental site trophoblastic tumor. The lesions may cause vaginal bleeding.
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